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KMID : 0438219760130020231
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Korea University Medical Journal
1976 Volume.13 No. 2 p.231 ~ p.246
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Studies on the antidotal effect of Panax Ginseng Especially the therapeutic effect of Ginseng on the acute alcoholism
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Abstract
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In order to investigate the influences of panax ginseng (white ginseng and red ginseng) on tire anesthetic effect and toxic effect of alcohol, following experimental studies had been carried out with albino rabbits, mongorian dogs and mice.
The anesthetic effect of alcohol was observed by measuring the induction time, anesthetic time, recovery time and duration from the beginning of induction to the recovery of anesthesia (total time), respectively, and toxic effect (LD;o) of alcohol were measured. In addition to these experiments, alcohol concentration in blood, blood sugar level, serum transaminase (GOT and GPT) activities and serum alkal_ne phosphatase activity were measured. Also in order to study the clinical effects of alcohol in healthy students, code substitution, response time and muscle coordnation were tested.
The results were obtained as follows;
1. In the rabbits and mongorian dogs, the induction time of anesthesia by administration of alcohol was delayed by the pretreatment of ginseng but recovery time and total time of anesthesia were markedly shortened.
2. The blood alcohol concentration was decreased by the pretreatment of ginseng but not affected in mongorian dogs.
3. The blood sugar level, serum transaminase(GOT and GPT) activities and alkaline phosphatase activity in rabbits and dogs induced by administration of alcohol were affected by the pretreatment of ginseng. Because those were included within normal ranges, the author was supposed to have no remarkable means.
4. Liver alcohol dehydrogenase activity of rabbit was increased by the pretreatment of ginseng, especially it was markedly increased by the pretreatment of red ginseng.
5. The average lethal dose of alcohol to mice was increased by the pretreatment of ginseng, especially it was markedly increased by the pretreatment of red ginseng.
6. In the clinical experments, the blood alcohol concentration induced by alcohol administration was not affected by the pretreatment of ginseng whereas the blood sugar level was increased. But these levels were within normal range. Blood alcohol concentration and blood sugar level were measured after 3 hours alcohol administration.
;. The response time of healthy students administered alcohol was markedly shortened by the pretreatment of ginseng but the experiments on the code substitution and muscle coordination were not affected.
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